litaba

E le sebopeho sa masapo a lihlahisoa tse ngata tsa tlhaho tse nang le bioactive le lithethefatsi (joalo ka dexamethadine e thibelang ho khohlela), morane o ka fumanoa ho tsoa ho li-derivatives tsa 1-benzyl octahydroisoquinoline ka mehato e meraro ea lik'hemik'hale tse arabelloang. asymmetric catalytic hydrogenation ea tšepe ea phetoho le ho hlatsuoa ha cyclohexamine oxidase le boramine, empa mekhoa ena ka kakaretso e na le likotsi tse kang stereoselective e fokolang, litšenyehelo tse phahameng tsa tlhahiso, moruo o fokolang oa athomo kapa ts'ilafalo e tebileng ea tikoloho.

Tianjin institute of biotechnology ea liindasteri, mofuputsi oa thuto ea mahlale oa China Zhu Duiming, Wu Qia ba etella pele sehlopha sa biocatalysis le green chemical, ba sebelisa Imine Reductase (Imine Reductase, IRED) ho fokotsa likhetho tsa alpha, beta unsaturated Imine (1 - benzyl six hydrogen isoquinoline derivatives), tokiso e atlehileng ea li-derivatives tse 1 - benzyl tse robeli tsa haidrojene tsa isoquinoline, bakeng sa sehlopha sena sa metsoako e fana ka mokhoa o sebetsang oa catalysis ea likokoana-hloko.

agfd

Phuputsong ena, laeborari ea imine reductase e ile ea hlahlojoa ka ho sebelisa selelekela sa dextromethorphan, mme ha fumanoa hore li-enzyme tse peli li bonts'itse li-stereoselective tse phahameng ka ho fetesisa, tse nang le enantiomer e fihletseng ho 98% (S) le>. ts'ebetso e ne e le 5.4 × 10-2 le 24.1 × 10-2 s-1 mm-1, ka ho latellana Motheong ona, ho ile ha thehoa karabelo ea liteko tsa laboratori, 'me chai ea karohano ea sehlahisoa e ne e le 74% le 80% ka tatellano. Kamora moo, ho ile ha fumanoa enzyme e nang le maemo a phahameng a tikoloho tokisetsong ea lihlahisoa tse nang le lintho tse fapaneng sebakeng sa p-position le ortho-position ea li-substrate tsa pele ho nako, tse ka fumanang lihlahisoa tse phahameng tsa stereoselectivity le karohano bakeng sa likarolo tsohle tse robeli, mme ea ba le menyetla e metle ea tlholisano ho feta mekhoa e teng ea pele ea metsoako ena.

Phuputso e tšehelitsoe ke motheo oa naha oa mahlale a tlhaho oa China (21778072) le khomishene ea mahlale ea tianjin (15PTCYSY00020 le 15PTGCCX00060) .Phuputso e sa tsoa phatlalatsoa koranteng Advanced catalysis & catalysis, mme e khethiloe e le Sehlooho se chesang sa bicatalysis Yao peiyuan, mofuputsi e mong oa tianjin institute of technology, le xu zefei, moithuti ea tsoang sekolong, ke bangoli ba etelletseng pele ba pampiri.


Nako ea poso: Mots'eanong-28-2020